Science

Foundational Substrate: Taurine

Human Clinical Data

Sun Q et al.
Taurine supplementation lowers blood pressure and improves vascular function in prehypertensive subjects.
Hypertension. 2016;67(3):541–549.
PMID: 26781281

Preclinical & Translational Data

Singh P et al.
Taurine deficiency as a driver of aging.
Science. 2023;380(6649):eabn9257.
PMID: 37204527

NAD⁺ Availability & Cellular Energy

Randomised Controlled Trial

Martens CR et al.
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD⁺ in healthy middle-aged and older adults.
Nature Communications. 2018;9:1286.
PMID: 29599478

Demonstrated significant elevation of NAD⁺ metabolites in healthy adults.

Randomised Controlled Trial

Mortensen SA et al.
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure (Q-SYMBIO).
JACC: Heart Failure. 2014;2(6):641–649.
PMID: 25282031

Reported clinical outcome improvements associated with CoQ10 supplementation in heart failure patients.

Stress Adaptation & Cognitive Fatigue

Double-Blind Cross-Over Study

Darbinyan V et al.
Phytomedicine. 2000;7(5):365–371.
PMID: 10839209

Improvement in mental performance and fatigue index scores under standardized Rhodiola extract.

Randomised, Double-Blind, Placebo-Controlled Trial

Olsson EMG et al.

Planta Medica. 2009;75(2):105–112.
PMID: 19294659

Reduction in stress-related fatigue and improvement in attention measures.

Immune & Systemic Resilience

Systematic Review and Meta-Analysis

Martineau AR et al.
BMJ. 2017;356:i6583.
PMID: 28202713

Individual participant data meta-analysis demonstrating reduction in acute respiratory infection risk with vitamin D supplementation.

Sleep & Recovery

Double-Blind, Placebo-Controlled Trial

Abbasi B et al.
Journal of Research in Medical Sciences. 2012;17(12):1161–1169.
PMID: 23853635

Improvement in insomnia measures following magnesium supplementation.

Human Volunteer Study

Inagawa K et al.
Sleep and Biological Rhythms. 2007;5(2):126–131.
PMID: 17910946

Improved subjective sleep quality following glycine ingestion.

Structural Biology

Review Article

Shoulders MD & Raines RT.
Annual Review of Biochemistry. 2009;78:929–958.
PMID: 19344236

Comprehensive review of collagen triple-helix structure and stability.

Biochemical Analysis

Meléndez-Hevia E et al.
Journal of Biosciences. 2009;34(6):853–872.
PMID: 20075598

Analysis of glycine demand in collagen synthesis relative to endogenous production.

Scope

• References relate to individual compounds studied under defined experimental conditions.
• Study populations, dosages, and durations vary.
• Multi-ingredient nutritional systems are typically constructed from ingredient-level evidence rather than full-formulation clinical trials.
• XORRO is a food supplement and is not intended to diagnose, treat, cure, or prevent disease.